Prepare to administer protamine sulfate.-rationale: frank hematuria indicates excessive anticoagulation and bleeding and heparin overdose. the nurse should discontinue the heparin infusion immediately and prepare to administer protamine sulfate, the antidote for heparin. decreasing the heparin infusion rate wouldnt prevent further bleeding. although the nurse should continue to monitor ptt, this action should occur later. an i.v. infusion of d5w may be administered, but only after protamine has been given.client needs category: physiological integrityclient needs subcategory: reduction of risk potentialcognitive level: applicationreference: smeltzer, s.c., et al. brunner & suddarths textbook of medical-surgical nursing, 11th ed. philadelphia: lippincott williams & wilkins, 2008, p. 1007.