Be sure to report skin irritation or other adverse reactions.-rationale: transdermal nitroglycerin can cause skin irritation; reporting this and other adverse reactions is the only correct instruction. the other options reflect incorrect teaching regarding transdermal nitroglycerin. the client should rotate the patch application site daily to prevent sensitization and tolerance; should avoid touching the medication-impregnated pad because touching it could cause drug absorption; and should store pads away from temperature and humidity extremes, which may inactivate the drug.client needs category: physiological integrityclient needs subcategory: pharmacological and parenteral therapiescognitive level: comprehensionreference: taylor, c., et al. fundamentals of nursing: the art and science of nursing care, 6th ed. philadelphia: lippincott williams & wilkins, 2008, p. 803.