Inject 35 units air into nph vial; inject 15 units air into regular insulin vial, withdraw 15 units regular insulin; withdraw 35 units nph.-rationale: to avoid creating a vacuum, the nurse must inject exactly the same amount of air into a multidose vial to replace the amount of medication to be withdrawn. she should follow these steps: (1) inject air into the vial from which the second insulin dose will be withdrawn (isophane insulin). (2) inject air into the vial from which insulin will be withdrawn first (regular insulin). (3) with the needle inserted into the regular insulin vial, withdraw the correct amount. (4) with 15 units of regular insulin in the syringe, carefully withdraw 35 units of nph, for a total of 50 units in the syringe. options 2 and 4 are incorrect because regular insulin must be withdrawn first. option 3 is incorrect because the nurse must not insert air into a multiple-dose vial with a syringe containing medication. client needs category: physiological integrity client needs subcategory: pharmacological and parenteral therapies cognitive level: application reference: taylor, c., et al. fundamentals of nursing: the art and science of nursing care,6th ed. philadelphia: lippincott williams & wilkins, 2008, p. 828.