Herpes zoster is an acute inflammation caused by the herpesvirus varicella-zoster (chickenpox) virus. it develops when the varicella-zoster virus is reactivated. Residual antibodies to the initial infection attempt to mobilize, but theyre ineffective. Fever, malaise, and red nodules develop in the dermatomes. the virus then multiplies in the ganglia, causing deep pain, itching, and paresthesia or hyperesthesia. Vesicles with clear fluid or pus appear. vesicles ultimately crust and scab and no longer shed the virus.