Inject ~ 35 mg of lignocaine as a \ bier\ s block\ ~ 30 - 120 secs before injection of propofol -anesthesia-intravensous ana agents-the most effective analgestic method was iv lignocaine, given as a biers block before the injection of propofol. of 100 the patients treated with lignocaine 40 mg with a rubber tourniquet at the forearm for 30 to 120s before the injection of propofol, approximately 60 would not have any pain who would have had pain had they not received lignocaine. metoclopramide is also a surprisingly effective method for reducing pain on injection. thei presumably reflects it structural similiarity to the local anaesthetics.