Macrophages-macrophages, present in such lesions, play a prominent role in the healing process. activated macrophages cansecrete various cytokines that promote angiogenesis and fibrosis, including platelet-derived growth factor, fibroblastgrowth factor, interleukin-1, and tumor necrosis factor. plasma cells can secrete immunoglobulins and are not instrumentalto healing of an area of tissue injury. neutrophils are most numerous within the initial 48 hours after infarction, but are notnumerous after the first week. eosinophils are most prominent in allergic inflammations and in parasitic infections.epithelioid cells, which are aggregations of activated macrophages, are typically seen with granulomatous inflammation.the healing of acute inflammatory processes does not involve granulomatous inflammation.bp7 5455bp8 5455pbd7 7981pbd8 54, 71
