Organism Z causes over 1 million causes of Z fever annually worldwide. Scientists have determined that a live, attenuated vaccine is most appropriate for this organism.
An intracellular bacterium-vaccines containing killed pathogens or antigenic components (subunits like peptides) do not enter host cells. hence, they induce a b cell-mediated humoral response. on the other hand, live attenuated live vaccines do penetrate cells, eliciting a cell-mediated immune response against intracellular antigens. so for intracellular organisms, live attenuated vaccines are more effective!Inactivated vaccines:inactivated vaccines, as the name implies, can produce a protective immune response without the risk of infection by the agent. they are used for agents that cannot be attenuated, that may cause recurrent infection, or that have onogenic potential.