What is the importance of citrate in fatty acid metabolism?

Activation of acetyl-coa carboxylase-fa synthesis and b-oxidation must not occur at the same time (futile cycle) compartmentalization: fa synthesis in cytosol, breakdown in mitocondria malonyl-coa (substrate for fa synthesis) shuts down carnitine shuttle (rate-limiting step of fa breakdown) fa synthesis regulated at acetyl-coa carboxylase: citrate signals good nutrition: allosteric insulin=dephosphorylation=activation glucagon + adrenalin=inc camp =phosphorylation=inactivation gene expression: insulin, glucagon# ( slide 57 f.a metab-bux)