What changes would be expected by a patient with Zollinger-Ellison syndrome?

Peptic ulcer disease

Zollinger-Ellison syndrome (gastrinoma) is a tumor of the non-b-cell pancreas. The tumor secretes gastrin, which then circulates to the gastric parietal cells to produce increased h+ secretion, peptic ulcer, and parietal cell growth (trophic effect of gastrin). Because the tumor does not involve the pancreatic b cells, insulin levels should be unaffected. absorption of lipids is decreased (not increased) because increased h + secretion decreases the ph of the intestinal lumen and inactivates pancreatic lipases.