Where does Carbon dioxide (CO 2) regulate blood flow?

Brain-blood flow to the brain is autoregulated by the pco2. if metabolism increases (or arterial pressure decreases), the pco2 will increase and cause cerebral vasodilation. blood flow to the heart and to skeletal muscle during exercise is also regulated metabolically, but adenosine and hypoxia are the most important vasodilators for the heart. adenosine, lactate, and k+ the are the most important vasodilators for exercising skeletal muscle. blood flow to the skin is regulated by the sympathetic nervous system rather than by local metabolites.