First, this question is missing a phrase that would help it make sense. Secondly, the answer is metabolic acidosis, or answer A. This is basically when something has accumulated in the body - usually an acid.
It can be caused by one of three key things: the body isn’t breaking down enough acid, the body is producing too much acid, or there isn’t enough of a base to off-set the acids in the body.
One of the biggest cases of metabolic acidosis actually led to the patient’s diagnosis of ethylene glycol poisoning. This case was covered on the television show “Forensic Files” and is a wonderful insight into the side effects of metabolic acidosis. I cannot recall what episode it was.