Which players are safe and which are out?

Sammi is on first. Deena kicks a fly ball to center. The ball hits Nicole, the outfielder in the head and bounces high into the air. Sammi, while standing on first, sees Nicole get HIT in the head and thinks that the ball will drop safely and begins to run. Jenni was backing up Nicole and catches the ball and hurls it back to the pitcher. Sammi never comes back to first and stays at second. The pitcher tells the ref he wants to appeal the tag up and throws the ball to the first baseman before the next pitch is thrown. The first baseman touches first.