Agouti is described as flecked and ticked. The guinea pig is able to breed year-round, with birth peaks usually coming in the spring; as many as five litters can be produced per year. The gestation period lasts from 59–72 days, with an average of 63–68 days. Because of the long gestation period and the large size of the pups, pregnant females may become large and eggplant-shaped, although the change in size and shape varies.
Unlike the offspring of most other rodents, which are altricial at birth, newborn pups are well-developed with hair, teeth, claws, and partial eyesight; they are immediately mobile, and begin eating solid food immediately, though they continue to suckle.