Beta thalassemia is associated with blood. If someone contracts Beta thalassemia, then they have a type of disorder in their blood. This has been contracted through hereditary means. One of the main symptoms or results of having this disorder is anemia which means there is low iron in someone’s blood. When a person suffers from beta thalassemia, their blood needs strengthening. So, the production of globin should be increased.
Doing this will cause the proteins in the blood to come together allowing for the oxygen in the blood to easily transport to the different areas of the body. More specifically, the patient needs alpha globin or a-globin because this type of protein is associated with genetics by using the HBA1 gene.
B-thalassemia major is characterized by very little or no -globin. This results in the formation of homotetramers (a4) which precipitate in the RBCs causing RBC destruction in the bone marrow and spleen. Increasing a-globin production would only exacerbate homotetramer formation and worsen the patients condition.
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