Reserpine -noradrenergic activity can be blocked by a number of mechanisms. reserpine, for example, prevents the synthesis and storage of norepinephrine in sympathetic nerve terminals. guanethidine sulfate affects noradrenergic transmission by blocking the release of norepinephrine at the sympathetic endings. competitive alpha-receptor blockers include phenoxybenzamine hydrochloride and phentolamine, whereas metoprolol blocks beta1 receptors. since ach is the transmitter at preganglionic synapses of both the parasympathetic and sympathetic nervous systems, hexamethonium chloride is an effective ganglionic blocker at these synapses.
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