That depends on what kind of modification has been done to the file. If the file has not been saved before, you will want to make sure you use the “save as” function of Microsoft Word. If the file has been saved before, then you have to options. You can click the “save” button in the home ribbon on the toolbar, or you can do the shortcut: control and “S”. (On a Mac, it’s command and “S”).
These two options will ultimately do the same thing. They will keep the modifications you’ve made to the file, and will keep a minimum backup of previous changes. These previous change backups are lost when you close the document. In newer versions of Word, there is an Autosave feature. If Word shuts down unexpectedly or because it’s not responding, Word will bring up the last modified and the original documents.