The main difference between speed and velocity is that speed does not have a particular direction. Speed is hence scalar quantity. On the other hand, velocity has a direction which makes it a vector quantity. Scalar quantities are those that are directionless, and do not change with a change in direction.
Hence, they are independent on direction. Vector quantities like velocity are dependent on the absolute direction, and hence with a change in direction, the velocity will change even if the magnitude of the velocity remains constant. This is the only main difference that exists between speed and velocity in physics.