Many people who suffer from bipolar and depression take either mood stabilizers or antidepressants, and quite often, both mood stabilizers such as lithium help to balance out the manic and depressive symptoms of bipolar disorder. It also helps to prevent recurrence and exacerbating symptoms, which is a perfect thing for those who have this condition.
Mood stabilizers act by decreasing neuronal activity to control overactive cellular mechanisms that cause both the mania and the depression. Antidepressants, on the other hand, treat depressive disorders. These medications typically work on serotonin, and it has been shown that people who are clinically depressed are lacking in serotonin.
There are also newer antidepressants that work on both serotonin and norepinephrine to give the depressed person an energy boost, as people who have depression accompanied by fatigue or lack of motivation. Medications like Wellbutrin and Cymbalta have this advantage to them. It is essential to note that anyone who has manic depression, and is currently taking a mood stabilizer, needs to be extremely careful with these types of antidepressants.