If in case you are familiar with these cars, you will know that they are both sedans. The Lexus E350 S is considered to be a powerful sedan. When it comes to the price, the Honda Accord is about $10,000 cheaper as compared to the Lexus E350S. The engine of the two is different.
The Honda Accord makes use of a 1.5-liter turbo engine while the Lexus E350S makes use of a 3.5-liter turbo engine. The transmission of the two is also different.
You can expect that the Accord will have a more basic transmission while the Lexus will have 8-speed automatic transmission. They both make use of the same FW drive.
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