A huge quantity of energy is released during these reactions of fission and fusion processes. However, the main difference between fission and fusion is that; fission is the splitting or separation of an atom to form smaller particles, while fusion is simply the formation of an atom by joining or fusing together of at least two smaller atoms into a larger one.
Fusion occurs in nature, such as in stars, and it evolves lighter elements. On the other hand, fission does not usually occur in nature but occurs with heavy elements such as uranium. The process of fission is initiated with a slow neutron and large critical mass. The fusion process takes place when the active force between two nuclei has the ability to overcome the binding electrostatic force, thus coming together very close. Considering the energy required to cause the reactions to work, fusion requires a lot of energy to fuse two nuclei, while fission requires little energy to split up atoms.