The significant difference between chromatin and chromosomes is that chromatin is unfolded DNA that exists as a complex of DNA and histone proteins. Meanwhile, chromosomes contain the highest condensed structure of the DNA double helix for the paper separation of the genetic material between daughter cells. Chromatin and chromosomes are two categories and structures of the double helix of DNA present in different stages of the cell. Chromatin is the usual form of packaged DNA within the cell.
On the other hand, chromosomes are the most critical structures during cell division, and they contain the genetic substance in the form of DNA, and this is because they are responsible for the transmission of heredity info from one generation to the next. Chromatin is a complex of DNA and histone proteins. Chromatin appears as long, thread-like structures. The primary function of chromatin is the easy package of genetic information of the cell into existence's eukaryotic nucleus.
Apart from its packaging, chromatin also allows DNA replication by regulating gene expression. It prevents DNA damage. A chromosome is the highest condensed structure of DNA double helix associated with histone proteins. Forty-six chromosomes are present in the human body's genome, while 23 pairs of homologous chromosomes along with two sex chromosomes.