Quarks and leptons are known to be particles that are more common in physics. These are particles that cannot be broken down anymore. Take note that some people say that they are not merely particles but rather families of particles that will stay together no matter what which explains why they cannot be broken down. One difference is their value.
A quark is known to have a fractional charge while a lepton comes with an integer charge. Another difference is their existence. Leptons have the ability to exist freely and easily while quarks will not be able to do that. There are also different fundamental forces that may affect both quarks and leptons. For example, the quark will not get affected by strong forces while the lepton will.