There is no much difference between Zyban and Wellbutrin. The two i.e Zyban and Wellbutrin are antidepressants and they are commonly prescribed to treat depression disorder and they are also used to help smokers combat nicotine addiction. But the difference between the two is that Zyban is mostly used to help smokers who are trying to quit smoking to combat nicotine addiction.
And Wellbutrin is mostly used to help those who are suffering from depression disorder to calm their mind and relax them so they can return to their normal state and begin to function effectively. The two drugs are produced by the same company, so the seeming difference between them is their names. The two drugs contain almost the same composition but are named separately because they are from the same company. That is why when you use Zyban to treat depression, it works perfectly and when you use Wellbutrin to cure nicotine addiction, it also works perfectly.