Demi is very prone to depression. In fact, it is out of control and is a disorder by this point and time. She suffers from a serious drug problem too and an eating disorder and also wanting to harm herself. So, yes, she is definately prone to depression. Sometimes the situation around a person leads them into deep depression but sometimes, it is a chemical imbalance and nothing going on with their lives.
For Demi, I believe it is both. Things have been rough for her being a child actress. Plus, there are problems within the family she grew up in. Add in some chemical imbalace and the stage is set for serious depression which she does have. Thankfully, there is help and all are hoping that she gets the professional help she needs now and can have a happy, healthy, normal life from here on out.