For over twenty-five years, antiprotons have been detected in cosmic rays, first by balloon-borne experiments and more recently by satellite-based detectors. The standard picture for their presence in cosmic rays is that they are produced in collisions of cosmic ray protons with nuclei in the interstellar medium, via the reaction, where A represents a nucleus.
The secondary antiprotons then propagate through the galaxy, restricted by the galactic magnetic fields. Their energy spectrum is modified by collisions with other atoms in the interstellar medium, and antiprotons can also be lost by "leaking out" of the galaxy.
Unlike protons, the antiprotons are a lot harder to make. They do not exist freely in nature like normal matter. To make the antiprotons, experimental labs use a 120 giga electron volt beam of protons taken from the main injector. This beam is incident through the side of a drum shaped target made of nickel.
The drum is rotated quickly to prevent the beam from hitting the same spot over and over. This prevents the destruction of the target. This collision with the target produces many particles a very small portion of which are antiprotons.