The Columbian Exchange is credited for the transfer of diseases from Europeans to Native Americans. Europeans and Native Americans suffered greatly from the diseases that were foreign to them.
The Old World diseases that were brought to the New World were Small Pox, Measles, Malaria and Chicken Pox and the New World diseases brought to the Old World were Syphilis and Polio.
The Natives were greatly affected by these diseases because they had never had exposure with these diseases and they had no immunity to them. The most deadly of the diseases was Small Pox; it is believed to have killed more than 50% of the native people.