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What decreases the conversion of 25-hydroxycholecalciferol to 1,25- dihydroxycholecalciferol?

What decreases the conversion of 25-hydroxycholecalciferol to 1,25- dihydroxycholecalciferol?<br/>

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Asked by Chachelly, Last updated: Nov 12, 2024

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Chachelly

Chachelly

Chachelly
Chachelly

Answered Dec 04, 2018

Chronic renal failure

Ca2deficiency (low Ca 2+ diet or hypocalcemia) activates lahydroxylase, which catalyzes the conversion of vitamin D to its active form, 1,25-dihydroxycholecalciferol. Increased parathyroid hormone (PTH) and hypophosphatemia also stimulate the enzyme. Chronic renal failure is associated with a constellation of bone diseases, including osteomalacia caused by failure of the diseased renal tissue to produce the active form of vitamin D.

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