Which of the following is false regarding simvastatin?

80 mg qhs should be the start dose in every patient

(D) is the false statement. 80 mg qhs is dangerous. The risks of adverse effects, such as myopathy are quite great. this dosage is reserved for those who have been taking it that high for at least 1 year. It shouldnt be the starting dose. (A) is true. Azole antifungals (fluconazole, itraconazole) are potent inhibitors of CYP enzymes. They are strictly contraindicated with simvastatin. (B) is also true. When taking either diltiazem or verapamil, the maximum dose of simvastatin is 10 mg qhs. (C) is true. When taking either amlodipine, amiodarone, or ranolazine, the maximum dose of simvastatin is 20 mg qhs. Just a quick note here. You may have noticed that the dosages of simvastatin are qhs. This is obviously deliberate. Simvastatin should be taken at bedtime because cholesterol synthesis goes up between meals (problematic during sleep). Simvastatin is at night because it has a relatively short half-life (about 3 hours). This is contrasted with atorvastatin, which has a 14-hour half-life and thus can be taken any time during the day.