Which of the following is the most relevant adverse effect of bile acid sequestrants?

Decreased absorption of other drugs

(B) is the correct answer. Because these are resins, they can bind to other drugs and decrease their natural absorption. This is a problem if the drug is already poorly absorbed. To account for this, other drugs should be taken 1 hour before or 4 hours after. This does include statins. (A) is false because bile acid sequestrants are not absorbed and systemic toxicities are not relevant. (C) is false because myopathy, relevant in other classes, is not relevant here. (D) is actually an important side effect, but the MAIN one. While abdominal discomfort is a common side effect, it tends to disappear as a person takes the drugs for a good amount of time.