Which drug parameters can be determined from this cumulative frequency distribution?

Median effective dose

14)Learning objective: describe the drug parameters that can be determined from a quantal log-doThe cumulative frequency distribution of subjects showing a desired effect is called quantal log dose response curve. From this curve, the dose that can produce that effect in 50% of individuals (called median effective dose) can be read on the abscissa. A) Affinity is the tendency of a drug to bind to a receptor. It can be measured by plotting the fraction of receptors bound by drug, against the log of the concentration of drug. It cannot be measured with a quantal log dose-response curve. C, D) The therapeutic index is a ratio between the toxic (TD50) and the effective (ED50) dose of a drug. The therapeutic window is the interval between the minimum effective dose (ED1) and the minimum toxic dose (TD1). In order to measure these variables, two quantal log dose-effect curves are needed. E) Maximal efficacy is the maximal effect a drug can produce. It can be measured with a grade log dose-effect curve, but not with a quantal log dose-effect curve.se effect curve