Increase in breast size or vascularity is consistent with cancer of the breast. Early menarche as well as late menopause or a history of anovulatory cycles are associated with fibrocystic disease. Masses associated with fibrocystic disease of the breast are firm. most often located in the upper outer quadrant of the breast. and increase in size prior to menstruation. They may be bilateral in a mirror image and are typically well demarcated and freely moveable.