DNA is positioned in the cell nucleus with the assistance of histones. In this situation, the nucleosome's primary level of DNA compaction is where the double helix is draped around the histone octamer comprising two copies of every histone. H2A, H2B, H3, and H4. Linker histone H1 connects the DNA between nucleosomes and facilitates the packaging of the 10nm fiber.
In the middle of cell divisions, chromatin is improved to permit easy access of transcription elements to active genes, which are typified by a less dense form known as euchromatin, and to relieve protein access in more tightly packed areas called heterochromatin.
For the cell division duration, chromatin compaction increases even more to form chromosomes, which can withstand large mechanical forces dragging them into each of the two daughter cells. Many transcription facets are regulated by chemical conversion on the histone proteins, known as the histone code. Eukaryotic DNA should be packed to be readily accessible inside the nucleus.