To be quiet and not say a word. George tells Lennie this when they were going to the ranch. At the beginning of the book, readers learn that Lennie is handicapped mentally. Due to his mental illness, he often forgets things.
This is why it is so important for George to remind Lennie to not say anything, because if he forgets he will spoil their chances at the ranch. Oftentimes, Lennie's forgetfulness got he and George into trouble and this time at the ranch would be no different if he did not stay quiet.
George instructs Lennie to be quiet and not say a word when they get to the ranch. Since this is found in chapter 1, there’s not much to spoil, but I’ll say it anyway: SPOILER ALERT. Lennie is mentally handicapped (the word “retarded” is used, but I find that it can be a bit repetitive to use only that word), and often forgets that he’s supposed to let George do all the talking.
Because of this, he’s gotten them into a lot of trouble before the novel even begins. The novel mentions that they had been run out of the last town due to Lennie’s obsession with petting soft things; he touched a woman’s dress because it looked soft and she screamed.