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Which of the following metabolic patterns would yu expec in the tumor lysis syndrome?

Which of the following metabolic patterns would yu expec in the tumor lysis syndrome?<br/>

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Asked by Mtoupe, Last updated: Dec 18, 2024

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mtoupe

mtoupe

mtoupe
Mtoupe

Answered Sep 03, 2018

Elevated potassium,elevated uric acid, low calcium

Rapid killing of tumor cells by cytotoxic therapy, especially in leukemia and lymhomas, can lead to an accelerated release of intracellular potassium, phosphate, and nucleic acid into the circulation. Phosphate binds to calcium, resulting in hypocalcemia, and the nucleic acids are converted to uric acid, resulting in hyperuricemia. This pattern may lead to cardiac arrhythmias and renal and or multiorgan dysfunction. Prevention with hypouricemic drugs (e.g. allopurinol) and IV hydration to maintain a urine flow of 150 to ml per hour prior to treatment is recommended. Alkalization of the urine with bicarbonate is also helpful.
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