A lot of thought and effort has gone into the making of Uncharted games but most of it is fantasy. The developer looked for gaps in historical recording and wrote stories that could possibly have occured, using imagination. The names of historical people are true and some of the locations.
All the rest is fantasy, but all fantasy has some point that connects with reality. Treat the historical part as a jump off point for a story. Then go to your history channels and look up the character to get more facts. This will actually add to your enjoyment as you play.