How is Kesley Grammer's life tragic and miserable?

Kelsey Grammar has dealt with a lot of family tragedy, as well as other hardships in his life. His father was shot, and his brothers died in a scuba diving accident. Also, in 1975, Grammar's younger sister, eighteen-year-old Karen Grammar was abducted, raped, and murdered by Freddie Glenn, Micheal Corbett and one other man. Kelsey was twenty years old at the time. He had to go and identify her body.

After that time he struggled with alcoholism and drug addiction. The guilt and pain compounded his obsession over his sister's murder. He has also had health problems. He had a heart attack, and his heart stopped. He is lucky to be alive.