With study of our universe and beyond, matters defying ordinary observation, we are dependent upon theories for discovering new facts. If scientific, theories make testable predictions which, if they turn out to be wrong, would mean that the theory must be discarded. With regard to the Big Bang, some of those predictions have been tested, some to very high precision, and turned out to be correct.
This is thanks to work such as Hubble's Law - distant objects are moving away from us; the cosmic microwave background - as the universe gets smaller its temperature rises; the abundance of helium - whereas the missing part of the proof of Big Bang - cosmic inflation, has been impossible to test. If inflation turns out to be not falsifiable, this would make it impossible to test using the scientific method. This part remains a theory yet to be proved.