Yes, the ozone layer is getting depleted day-by-day. Chlorofluorocarbons (CFC) and halogens (bromine atoms) come in contact with ozone in the stratosphere, CFC and halogens destroy the ozone layer. It has been recorded that 1 chlorine atom is capable of destroying 100,000 ozone molecules before the atom is being removed from the stratosphere. It will take years to naturally create the destroyed molecules.
Ozone layer depletion allows UVB radiation to reach the earth. UVB radiation is a type of ultraviolet light that comes from the sun, it has many harmful effects on humans. UVB radiation has been associated with DNA damage, melanoma and many other types of skin cancer.
Sadly, yes. Massive use of chemicals containing chlorine (CFCs) found mainly in spray aerosols heavily used by industrialized nations for much of the past 50 years, have largely caused ozone layer breakdown.
Some countries still use them. One atom of chlorine can destroy more than a hundred thousand ozone molecules. Although agricultural spraying has been banned for two decades, it will take around 50 years for those molecules to return to their natural level.