Due to both the short story and the recent movie about the Orient Express, Agatha Christie made this train ride very famous and popular. Many people enjoy traveling on this luxurious train ride due to its luxury and its namesake. The cost of the trip on the Orient Express depends on where you are going. It also depends where the train is coming from.
Some trips begin in Germany in Berlin, but others are in other major cities in Europe. The cost also depends on the type of cabin you are wanting. They have double and single rooms and cabin suites. For the most part, the cheapest fare is 2,000 pounds and the most can be 40,000 pounds. Then there are some costs in between. It also depends upon the number of nights on the train.
The Orient Express does not technically exist, however, there is the Venice Simplon Orient Express. This is about the closest thing you'll get—you won't be disappointed, but it won't be cheap. Generally speaking, this is a first-class route not meant solely for transportation. It is meant more as a high-end journey with hands-on service and top-notch food.
There are a couple companies that run this route both charging a minimum of $2500 for base accommodations from Venice to London. There are different routes different companies as well as packages offered. Regardless of what route or the types of cabin chosen, you are guaranteed to have a luxurious time.