I have not personally experimented with psychedelic drugs because I have read about the dangerous side effects. I have heard that people claim to experience life altering sensations while on psychedelics but in my opinion, those experiences are not real. The experiences they have while on psychedelics are really just hallucinations.
To me, an amazing experience is something that happens in real life, not something that is manufactured through a drug. For those who want to have an amazing life altering experience, I would recommend trying an adventure sport that gets your adrenaline pumping so that you have a natural high.